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Keiji UedaProfessorDivision of VirologyDepartment of Microbiology and ImmunologyOsaka University Graduate School of MedicineJapanTel: 81-6-879-3780
Research Interest• Studies on viruses enter into cells, express their genes, amplify the genomes, assemble virus particles and egress out of cells
An aim of virologyattachment/entrygene expression/replicationexecute through virus-host interaction制制to learn elaborate viral strategies and to regulate them !!assembly and egresshttp://www.med.osaka-u.ac.jp:80/pub/virus/KSHV HBV
KSHV replication in latency?-LANA 、 ori-P-ORC2-62-6ORC1ORC2-6-ORC1LANAORCsori-PGCLBSLANAKSHV genomeORC2-6-ORC1GCLBSKSHV genomeCdt1Cdc6 MCM2-7ori-PGCLBSLANAKSHV genomeORC2-6-ORC1MCM2-7Pre-RCviral genome epigenetics?-strict gene regulation in latency-LANAv-Cycv-FLIPK12ori-LytK14ORF69heterochromatin heterochromatinInsulator?HBV recepotor & HBVpol assay systemLTR LTRgfphygrintegrationnucleuscDNAHyg-selected cellsHBV pseudotypePirated genes• vIRFs• vMIPs• vIL-6• vBCL-2• vCYC• vFLIP✗Host original genes• IRFs• MIPs• IL-6• BCL-2• CYCD• FLIP i i l • I s• I s• I -• -•• Ivirus host interaction?cancerLatent cyclelytic cycleaneuploidyLANA LANAmis-segregationKSHV oncogenesis ?Problems we are challenging to solve
Journal of Infectious Diseases and Therapy Bacteriology & Parasitology Clinical Microbiology: Open Access Virology & Antiviral Research Virology & Mycology
2nd International Congress on Bacteriology and Infectious Diseases 3rd International Conference on Clinical Microbiology & Microbial Genomics Journal of Infectious Diseases and Therapy
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